Rapid Anticoagulation Lithium Heparin Tube Green Top Tube Na

Lithium Heparin & Rapid Anticoagulation Capability - Most Economical Solution

Lithium Heparin is a salt form of heparin widely used as an in vitro anticoagulant, synthesized by binding heparin with lithium ions. It appears as a white amorphous powder, soluble in water, with an average molecular weight of 15,000 and CAS number 9045-22-1.

• Anticoagulation Mechanism: Reversibly binds to Antithrombin III (ATIII), enhancing its inhibition of thrombin and Factor Xa. This increases the thrombin inhibition rate by 2,000-fold, preventing blood clot formation rapidly.
• Minimal Ionic Interference: Superior compatibility with electrolyte tests (e.g., Na⁺, K⁺, Ca²⁺) compared to sodium heparin or EDTA, reducing analytical bias.
• Stability: Stable at room temperature in solid form (shelf life: 3 years), but aqueous solutions require refrigeration (0-4°C) and must be used within 7 days.

Lithium heparin is primarily applied in clinical biochemistry and research:

• Emergency Biochemistry Testing: Rapid anticoagulation (immediate gentle inversion 5-8 times post-collection) enables quick processing without clot formation.
• Electrolyte and Metabolite Assays: Ideal for sodium, potassium, creatinine, uric acid, glucose, liver enzymes (ALT/AST), and lipid profiles due to low ion interference.
• Therapeutic Drug Monitoring (TDM): Measures drug concentrations (e.g., antibiotics) in heparinized plasma.
• Research: Inhibits IP3-activated calcium channels in cell studies or investigates coagulation pathways.

• Mixing Protocol: Tubes must be inverted gently post-collection; vigorous shaking causes hemolysis.
• Time Sensitivity: Samples should be tested within 6 hours, as prolonged storage affects enzyme stability (e.g., ALT, GGT).
• Interference Risks: Excess heparin may alter magnesium/phosphate levels; optimal concentration is ≥150 IU/mg.